Journal article

Modelling the dorsal root ganglia using human pluripotent stem cells: A platform to study peripheral neuropathies

Serena Viventi, Mirella Dottori

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2018

Abstract

Sensory neurons of the dorsal root ganglia (DRG) are the primary responders to stimuli inducing feelings of touch, pain, temperature, vibration, pressure and muscle tension. They consist of multiple subpopulations based on their morphology, molecular and functional properties. Our understanding of DRG sensory neurons has been predominantly driven by rodent studies and using transformed cell lines, whereas less is known about human sensory DRG neurons simply because of limited availability of human tissue. Although these previous studies have been fundamental for our understanding of the sensory system, it is imperative to profile human DRG subpopulations as it is becoming evident that human ..

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University of Melbourne Researchers