Journal article

The effects of cannabidiol on persecutory ideation and anxiety in a high trait paranoid group.

Harneet Hundal, Rachel Lister, Nicole Evans, Angus Antley, Amir Englund, Robin M Murray, Daniel Freeman, Paul D Morrison

J Psychopharmacol | Published : 2018


BACKGROUND: Previous studies have suggested that cannabidiol has anxiolytic and antipsychotic properties, raising hopes that cannabidiol will translate to the psychiatric clinic. Cannabidiol may be particularly useful for anxiety and paranoia in those at-risk of major mental illness. METHODS: Immersion in a controlled 3D virtual-reality scenario was used to assay persecutory ideation and anxiety in a sample of non-clinical volunteers ( n=32) pre-selected for high paranoid traits. Participants were randomised to receive oral cannabidiol (600 mg) or placebo 130 min prior to entering virtual-reality. Well-validated rating scales were used to assay persecutory thinking and anxiety. Salivary cort..

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University of Melbourne Researchers