Traditional marijuana, high-potency cannabis and synthetic cannabinoids: increasing risk for psychosis.
Robin M Murray, Harriet Quigley, Diego Quattrone, Amir Englund, Marta Di Forti
World Psychiatry | Published : 2016
Epidemiological evidence demonstrates that cannabis use is associated with an increased risk of psychotic outcomes, and confirms a dose-response relationship between the level of use and the risk of later psychosis. High-potency cannabis and synthetic cannabinoids carry the greatest risk. Experimental administration of tetrahydrocannabinol, the active ingredient of cannabis, induces transient psychosis in normal subjects, but this effect can be ameliorated by co-administration of cannabidiol. This latter is a constituent of traditional hashish, but is largely absent from modern high-potency forms of cannabis. Argument continues over the extent to which genetic predisposition is correlated to..View full abstract