Expanding the range of ZNF804A variants conferring risk of psychosis.

S Steinberg; O Mors; AD Børglum; O Gustafsson; T Werge; PB Mortensen; OA Andreassen; E Sigurdsson; TE Thorgeirsson; Y Böttcher; P Olason; RA Ophoff; S Cichon; IH Gudjonsdottir; OPH Pietiläinen; M Nyegaard; A Tuulio-Henriksson; A Ingason; T Hansen; L Athanasiu; J Suvisaari; J Lonnqvist; T Paunio; A Hartmann; G Jürgens; M Nordentoft; D Hougaard; B Norgaard-Pedersen; R Breuer; H-J Möller; I Giegling; B Glenthøj; HB Rasmussen; M Mattheisen; I Bitter; JM Réthelyi; T Sigmundsson; R Fossdal; U Thorsteinsdottir; M Ruggeri; S Tosato; E Strengman; Genetic Risk and Outcome in Psychosis; LA Kiemeney; I Melle; S Djurovic; L Abramova; V Kaleda; M Walshe; E Bramon; E Vassos; T Li; G Fraser; N Walker; T Toulopoulou; J Yoon; NB Freimer; RM Cantor; R Murray; A Kong; V Golimbet; EG Jönsson; L Terenius; I Agartz; H Petursson; MM Nöthen; M Rietschel; L Peltonen; D Rujescu; DA Collier; H Stefansson; D St Clair; K Stefansson

Journal article

Expanding the range of ZNF804A variants conferring risk of psychosis.

S Steinberg, O Mors, AD Børglum, O Gustafsson, T Werge, PB Mortensen, OA Andreassen, E Sigurdsson, TE Thorgeirsson, Y Böttcher, P Olason, RA Ophoff, S Cichon, IH Gudjonsdottir, OPH Pietiläinen, M Nyegaard, A Tuulio-Henriksson, A Ingason, T Hansen, L Athanasiu Show all

Molecular Psychiatry | Published : 2011

DOI: 10.1038/mp.2009.149

Abstract

A trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P<5 × 10(-8)) associated with schizophrenia earlier. However, one variant, rs1344706[T], had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6 × 10(-7), and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0 × 10(-8). In this study, using 5164 schizophrenia cases and 20,709 controls, we replicated the association with schizophrenia (odds ratio OR = 1.08, P = 0.0029) and, by adding bipolar disord..

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