Interaction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function.
Andreina Pauli, Diana P Prata, Andrea Mechelli, Marco Picchioni, Cynthia HY Fu, Christopher A Chaddock, Fergus Kane, Sridevi Kalidindi, Colm McDonald, Eugenia Kravariti, Timothea Toulopoulou, Elvira Bramon, Muriel Walshe, Natascha Ehlert, Anna Georgiades, Robin Murray, David A Collier, Philip McGuire
Hum Brain Mapp | Published : 2013
The genes for the dopamine transporter (DAT) and the D-Amino acid oxidase activator (DAOA or G72) have been independently implicated in the risk for schizophrenia and in bipolar disorder and/or their related intermediate phenotypes. DAT and G72 respectively modulate central dopamine and glutamate transmission, the two systems most robustly implicated in these disorders. Contemporary studies have demonstrated that elevated dopamine function is associated with glutamatergic dysfunction in psychotic disorders. Using functional magnetic resonance imaging we examined whether there was an interaction between the effects of genes that influence dopamine and glutamate transmission (DAT and G72) on r..View full abstract
Awarded by Medical Research Council
Awarded by Department of Health