Meta-analytic approaches to determine gender differences in the age-incidence characteristics of schizophrenia and related psychoses.
Dan Jackson, James Kirkbride, Tim Croudace, Craig Morgan, Jane Boydell, Antonia Errazuriz, Robin M Murray, Peter B Jones
International Journal of Methods in Psychiatric Research | Published : 2013
A recent systematic review and meta-analysis of the incidence and prevalence of schizophrenia and other psychoses in England investigated the variation in the rates of psychotic disorders. However, some of the questions of interest, and the data collected to answer these, could not be adequately addressed using established meta-analysis techniques. We developed a novel statistical method, which makes combined use of fractional polynomials and meta-regression. This was used to quantify the evidence of gender differences and a secondary peak onset in women, where the outcome of interest is the incidence of schizophrenia. Statistically significant and epidemiologically important effects were ob..View full abstract