BDNF gene polymorphism, cognition and symptom severity in a Brazilian population-based sample of first-episode psychosis subjects.
Eduardo Martinho, Leandro Michelon, Adriana M Ayres, Marcia Scazufca, Paulo R Menezes, Maristela S Schaufelberger, Robin M Murray, Teresa M Rushe, Homero Vallada, Geraldo Busatto Filho
Braz J Psychiatry | Published : 2012
OBJECTIVE: To investigate the influence of brain-derived neurotrophic factor (BDNF) gene variations on cognitive performance and clinical symptomatology in first-episode psychosis (FEP). METHODS: We performed BDNF val66met variant genotyping, cognitive testing (verbal fluency and digit spans) and assessments of symptom severity (as assessed with the PANSS) in a population-based sample of FEP patients (77 with schizophreniform psychosis and 53 with affective psychoses) and 191 neighboring healthy controls. RESULTS: There was no difference in the proportion of Met allele carriers between FEP patients and controls, and no significant influence of BDNF genotype on cognitive test scores in either..View full abstract