Journal article

BDNF gene polymorphism, cognition and symptom severity in a Brazilian population-based sample of first-episode psychosis subjects.

Eduardo Martinho, Leandro Michelon, Adriana M Ayres, Marcia Scazufca, Paulo R Menezes, Maristela S Schaufelberger, Robin M Murray, Teresa M Rushe, Homero Vallada, Geraldo Busatto Filho

Braz J Psychiatry | Published : 2012

Abstract

OBJECTIVE: To investigate the influence of brain-derived neurotrophic factor (BDNF) gene variations on cognitive performance and clinical symptomatology in first-episode psychosis (FEP). METHODS: We performed BDNF val66met variant genotyping, cognitive testing (verbal fluency and digit spans) and assessments of symptom severity (as assessed with the PANSS) in a population-based sample of FEP patients (77 with schizophreniform psychosis and 53 with affective psychoses) and 191 neighboring healthy controls. RESULTS: There was no difference in the proportion of Met allele carriers between FEP patients and controls, and no significant influence of BDNF genotype on cognitive test scores in either..

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University of Melbourne Researchers