Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis?
Monica Aas, Serena Navari, Ayana Gibbs, Valeria Mondelli, Helen L Fisher, Craig Morgan, Kevin Morgan, James MacCabe, Abraham Reichenberg, Jolanta Zanelli, Paul Fearon, Peter B Jones, Robin M Murray, Carmine M Pariante, Paola Dazzan
Schizophrenia Research | Published : 2012
Patients with psychosis have higher rates of childhood trauma, which is also associated with adverse effects on cognitive functions such as attention, concentration and mental speed, language, and verbal intelligence. Although the pathophysiological substrate for this association remains unclear, these cognitive deficits may represent the functional correlate of changes observed in relation to trauma exposure in structures such as the amygdala and the hippocampus. Interestingly, these structures are often reported as altered in psychosis. This study investigated the association between childhood trauma, cognitive function and amygdala and hippocampus volume, in first-episode psychosis. We in..View full abstract
Awarded by Wellcome Trust
Awarded by Medical Research Council