5-HT2A receptor and bipolar affective disorder: association studies in affected patients.
MJ Arranz, J Erdmann, G Kirov, M Rietschel, M Sodhi, M Albus, D Ball, W Maier, N Davies, E Franzek, I Abusaad, B Weigelt, R Murray, D Shimron-Abarbanell, R Kerwin, P Propping, P Sham, MM Nöthen, DA Collier
Neurosci Lett | Published : 1997
The aim of this study was to investigate the possible involvement of genetic variation in serotonin receptors in the aetiology of bipolar affective disorder. The 5-HT2A receptor gene was systematically screened for genetic variants by single strand conformation polymorphism (SSCP) methods in subjects with bipolar affective disorder. Four polymorphisms (two structural changes, Thr25Asn and His4 M52Tyr, and two silent polymorphisms, 102-T/C and 516-C/T) which had previously been found in patients with schizophrenia and control subjects were detected. No novel polymorphisms were found in patients with bipolar affective disorder. These polymorphisms were genotyped in a sample of 129 patients and..View full abstract