Genetic association of the HLA DRB1 gene locus on chromosome 6p21.3 with schizophrenia.
P Wright, PT Donaldson, JA Underhill, K Choudhuri, DG Doherty, RM Murray
Am J Psychiatry | Published : 1996
OBJECTIVE: The authors investigated the human leukocyte antigen (HLA) DRB1*04 gene in schizophrenic patients because it is positively associated with rheumatoid arthritis, an autoimmune disease that exhibits a strong negative association with schizophrenia. The HLA DQB1*0602 allele was also studied because of previous reports of genetic association between it and schizophrenia. Maternal HLA was investigated because of the reported association between prenatal influenza and schizophrenia and the central role of HLA molecules in the immune response to viral infections. METHOD: Polymerase chain reactions and sequence-specific oligonucleotide probes were used to genotype 94 unrelated patients wi..View full abstract