PRODH gene is associated with executive function in schizophrenic families.
Tao Li, Xiaohong Ma, Xun Hu, Yingcheng Wang, Chengying Yan, Huaqing Meng, Xiehe Liu, Timothea Toulopoulou, Robin M Murray, David A Collier
Am J Med Genet B Neuropsychiatr Genet | Published : 2008
The aim of this study was to investigate the relationship between polymorphisms in the PRODH and COMT genes and selected neurocognitive functions. Six SNPs in PRODH and two SNPs in COMT were genotyped in 167 first-episode schizophrenic families who had been assessed by a set of 14 neuropsychological tests. Neuropsychological measures were selected as quantitative traits for association analysis. The haplotype of SNPs PRODH 1945T/C and PRODH 1852G/A was associated with impaired performance on the Tower of Hanoi, a problem-solving task mainly reflecting planning capacity. There was no significant evidence for association with any other neuropsychological traits for other SNPs or haplotypes of ..View full abstract