Brain structure and neurocognitive and behavioural function in adolescents who were born very preterm.
AL Stewart, L Rifkin, PN Amess, V Kirkbride, JP Townsend, DH Miller, SW Lewis, DP Kingsley, IF Moseley, O Foster, RM Murray
Lancet | Published : 1999
BACKGROUND: Infants born very preterm (<33 weeks) are at increased risk of neurocognitive deficits. Their neurodevelopmental outcome up to age 8 years can be predicted by neonatal ultrasonography, but little is known of their later function. We investigated the effect of very preterm birth on brain structure and neurocognitive and behavioural functioning in adolescence. METHODS: A cohort of 105 infants born before 33 weeks of gestation in 1979-80 had ultrasonographic scans at University College Hospital, London, and were prospectively examined at 1, 4, and 8 years. At age 14-15 years, 72 of those who remained in UK (cases) and 21 age-matched full-term controls underwent brain magnetic resona..View full abstract
Awarded by Multiple Sclerosis Society