Fetal brain development and later schizophrenia.
RM Murray, P Jones, E O'Callaghan
Ciba Found Symp | Published : 1991
Computed tomography and magnetic resonance imaging studies have shown cerebral ventricular enlargement and a decreased volume of temporal lobe structures in a proportion of schizophrenic patients. Neuropathological investigations confirm these findings and also show diminished volume of the hippocampus and abnormal pre-alpha cell clusters in the parahippocampal gyrus. Compared with controls, schizophrenic patients are more likely to have minor physical anomalies, to have a history of obstetric complications, and to have been born in the late winter. Together the evidence regarding structural brain abnormalities and epidemiology suggests that a significant proportion of cases of schizophrenia..View full abstract