Journal article

Multilevel Modeling of Cognitive Function in Schizophrenic Patients and Their First Degree Relatives.

S Rabe-Hesketh, T Toulopoulou, RM Murray

Multivariate Behavioral Research | Published : 2001


We describe multilevel modeling of cognitive function in subjects with schizophrenia, their healthy first degree relatives and controls. The purpose of the study was to compare mean cognitive performance between the three groups after adjusting for various covariates, as well as to investigate differences in the variances. Multilevel models were required because subjects were nested within families and some of the measures were repeated several times on the same subject. The following four methodological issues that arose during the analysis of the data are discussed. First, when the random effects distribution was not normal, non-parametric maximum likelihood (NPML) was employed, leading to..

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