Further evidence that congenital dermatoglyphic abnormalities are associated with psychosis: a twin study.
Araceli Rosa, Lourdes Fañanás, Jim van Os, Tracy Ribchester, Nadia Davies, Bárbara Arias, Alison McDonald, Robin M Murray
Schizophr Bull | Published : 2002
The presence of abnormal palmar flexion creases (APFC) and dermatoglyphic ridge dissociation (RD) may constitute enduring evidence of a prenatal insult that occurred before the third trimester of intrauterine life. We examined these dermatoglyphic abnormalities in a twin study of psychotic disorders. RD and APFC were analyzed in a monozygotic (MZ) twin sample from the Maudsley Hospital in London (11 normal control pairs, 16 pairs concordant for psychosis, 9 pairs discordant for psychosis, 1 concordant triplet, and 1 triplet with one affected member). The risk of either RD or APFC was 44 percent in affected twins and 20 percent in nonaffected twins (odds ratio = 3.25, 95% confidence interval:..View full abstract