Journal article

Physical activity and the risk of colorectal cancer in Lynch syndrome

S Ghazaleh Dashti, Aung Ko Win, Sheetal S Hardikar, Stephen E Glombicki, Sheila Mallenahalli, Selvi Thirumurthi, Susan K Peterson, Y Nancy You, Daniel D Buchanan, Jane C Figueiredo, Peter T Campbell, Steven Gallinger, Polly A Newcomb, John D Potter, Noralane M Lindor, Loic Le Marchand, Robert W Haile, John L Hopper, Mark A Jenkins, Karen M Basen-Engquist Show all

INTERNATIONAL JOURNAL OF CANCER | WILEY | Published : 2018

Abstract

Greater physical activity is associated with a decrease in risk of colorectal cancer for the general population; however, little is known about its relationship with colorectal cancer risk in people with Lynch syndrome, carriers of inherited pathogenic mutations in genes affecting DNA mismatch repair (MMR). We studied a cohort of 2,042 MMR gene mutations carriers (n = 807, diagnosed with colorectal cancer), from the Colon Cancer Family Registry. Self-reported physical activity in three age-periods (20-29, 30-49 and ≥50 years) was summarized as average metabolic equivalent of task hours per week (MET-hr/week) during the age-period of cancer diagnosis or censoring (near-term exposure) and acro..

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Grants

Awarded by National Cancer Institute


Awarded by Fred Hutchinson Cancer Research Center


Awarded by Hawaii Department of Health, SEER Program of the National Cancer Institute


Awarded by California Department of Public Health, SEER Program of the National Cancer Institute


Awarded by National Health and Medical Research Council (NHMRC), Australia


Awarded by University of Melbourne Research at Melbourne Accelerator Program (R@MAP)


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

Grant sponsor: National Cancer Institute; Grant numbers: UM1 CA167551 (Colon Cancer Family Registry), U01 CA074778, U01/U24 CA097735 (Australasian Colorectal Cancer Family Registry), U01/U24 CA074800 (Mayo Clinic Cooperative Family Registry for Colon Cancer Studies), U01/U24 CA074783 (Ontario Familial Colorectal Cancer Registry), U01/U24 CA074794 (Seattle Colorectal Cancer Family Registry), U01/U24 CA074806 (University of Hawaii Colorectal Cancer Family Registry), U01/U24 CA074799 (USC Consortium Colorectal Cancer Family Registry), K07CA160753 (MP), R25CA056452 (SM) and P30CA016672 (MD Anderson Cancer Center Core Grant); Grant sponsor: Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute with additional support from the Fred Hutchinson Cancer Research Center; Grant numbers: N01-CN-67009, N01-PC-35142, HHSN2612013000121 (Cancer Surveillance System of the Fred Hutchinson Cancer Research Center); Grant sponsor: Hawaii Department of Health, SEER Program of the National Cancer Institute; Grant numbers: N01-PC-67001, N01-PC-35137, HHSN26120100037C (University of Hawaii); Grant sponsor: California Department of Public Health, SEER Program of the National Cancer Institute; Grant numbers: HHSN261201000140C (Cancer Prevention Institute of California), HHSN261201000035C (University of Southern California); Grant sponsor: US State Cancer Registries: AZ, CO, MN, NC, and NH; Grant sponsor: Victorian Cancer Registry, Australia, and the Ontario Cancer Registry, Canada; Grant sponsor: National Health and Medical Research Council (NHMRC), Australia; Grant numbers: APP1074383 (program grant), APP1073395 (Early Career Fellowship to AKW), APP1117611 (Senior Research Fellowship to MAJ), APP1023434 (Senior Principal Research Fellowship to JLH), APP1125268 (R.D. Wright Career Development Fellowship to DDB); Grant sponsor: University of Melbourne Research at Melbourne Accelerator Program (R@MAP); Grant number: 13947 (Senior Research Fellowship to DDB); Grant sponsor: Center for Energy Balance in Cancer Prevention and Survivorship, Duncan Family Institute (KBE)