Journal article

COMPARISON OF ADRENOCORTICOTROPIN CONTROL IN BRATTLEBORO, LONG-EVANS, AND WISTAR RATS - MEASUREMENT OF CORTICOTROPIN-RELEASING FACTOR, ARGININE VASOPRESSIN, AND OXYTOCIN IN HYPOPHYSEAL PORTAL BLOOD

LA TANNAHILL, RC DOW, KM FAIRHALL, ICAF ROBINSON, G FINK

NEUROENDOCRINOLOGY | KARGER | Published : 1988

Abstract

The purpose of this study was to compare the control of adrenocorticotropin (ACTH) and corticosterone secretion in homozygous Brattleboro rats with their syngeneic controls, Long-Evans rats, and with rats of the Wistar strain. Plasma concentrations of ACTH and corticosterone were measured by radioimmunoassay in trunk blood, and corticotropin-releasing factor 41 (CRF-41), arginine vasopressin (AVP), and oxytocin were assayed in hypophysial portal vessel blood. Portal plasma was extracted with methanol for CRF-41 determination, and four different antisera and several different high-performance liquid chromatography (HPLC) systems were used to investigate AVP release. The peripheral plasma conc..

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