Antibodies to normal and Alzheimer human brain structures from non-immunised mice of various ages

Abstract

Supernatants from mouse spleen hybridoma lines established without previous immunisation were screened immunohistochemically against cryostat sections of human temporal cortex and found to stain a variety of brain structures, including Alzheimer plaques and tangles. The age of the mice had no effect on antibody production. © 1987.