Journal article

TESTOSTERONE INDUCES AN ALL-OR-NONE, EXPONENTIAL INCREASE IN ARGININE VASOPRESSIN MESSENGER-RNA IN THE BED NUCLEUS OF STRIA TERMINALIS OF THE HYPOGONADAL MOUSE

R ROSIE, H WILSON, G FINK

MOLECULAR AND CELLULAR NEUROSCIENCE | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS | Published : 1993

Abstract

The bed nucleus of the stria terminalis (BNST) in rodents contains arginine vasopressin (AVP) neurons which project to the lateral septum (LS) and habenula (LH) and are thought to be important for social recognition or memory. In previous studies we demonstrated that AVP immunoreactivity in the LS and LH is absent in the hypogonadal (hpg) mouse and that AVP immunoreactivity in the LH and LS of this mutant can be induced by testosterone. The aim of the present study was to determine whether this action of testosterone was due to the induction of AVP gene expression in BNST neurons and if so the time taken for testosterone to exert its effect. We found that exposure to supraphysiological conce..

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