Journal article

ASTROCYTES IMMUNOREACTIVE FOR GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) ARE INCREASED IN THE MEDIOBASAL HYPOTHALAMUS IN HYPOGONADAL (HPG) MICE

JK MCQUEEN, AK WRIGHT, GW ARBUTHNOTT, G FINK

MOLECULAR AND CELLULAR NEUROSCIENCE | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS | Published : 1992

Abstract

The actions of gonadal steroids on neuronal activity in the hypothalamus are well documented, but the effects on glial cells are less clear. Here we have investigated glial cell activity in normal and hypogonadal (hpg) mice, in which gonadal development is arrested postnatally. Astrocytes immunoreactive for filial fibrillary acidic protein (GFAP) were examined throughout the hypothalamus, using immunohistochemical techniques. The number of GFAP immunoreactive (GFAP-IR) cells was 25-fold higher in the mediobasal hypothalamus of hpg compared with normal mice, but there was no evidence of a sex difference in either hpg or normal mice. Castration of normal mice on the fifth postnatal day did not..

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