Journal article

The Human Amyloid Precursor Protein Binds Copper Ions Dominated by a Picomolar-Affinity Site in the Helix-Rich E2 Domain

Tessa R Young, Tara L Pukala, Roberto Cappai, Anthony G Wedd, Zhiguang Xiao

Biochemistry | AMER CHEMICAL SOC | Published : 2018

DOI: 10.1021/acs.biochem.8b00572

Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by funds from Australian Research Council Grant DP130100728. Additional financial support for T.R.Y. was generously provided by the Norma Hilda Schuster (nee Swift) Scholarship Fund and the Albert Shimmins Fund.

Citation metrics

4Web of Science
4Scopus

Keywords

Protein Binding
Protein Domains
Crystallography, X-Ray
Expression
Science & Technology
Models, Molecular
Amyloid Beta-Protein Precursor
Crystal-Structure
Serum Albumin, Human
Heparin-Induced Dimerization
App
Biochemistry & Molecular Biology
Mass-Spectrometry
Humans
Quantification
Life Sciences & Biomedicine
Copper
Binding Sites
Nmda Receptor
Cu(i) Binding
Metal-Binding
Alzheimers-Disease