Synthesis of a deoxyguanosine monophosphate rich propyl methacrylate oligomer
Michael J Wilson, Renzo A Fenati, Elizabeth GL Williams, Amanda V Ellis
NEW JOURNAL OF CHEMISTRY | ROYAL SOC CHEMISTRY | Published : 2018
We report on the first synthesis of a "protected" 5′-dimethoxytrityl-N-isobutyryl-2′-deoxyguanosine(dG), 3′-[(2-cyanoethyl)-2-(methacryloyloxy)propyl]-monophosphate monomer through a modified phosphoramidite coupling method. Here, 2-hydroxylpropyl methacrylate (HPMA) was coupled to a protected 5′-dimethoxytrityl-N-isobutyryl-2′-deoxyguanosine, 3′-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Subsequent reversible addition fragmentation chain transfer (RAFT) polymerisation of the protected monomer, followed by deprotection, produced poly[2-(deoxyguanosine-3′-phospho)propyl methacrylate] (poly(dG-P-PMA)). In situ1H nuclear magnetic resonance spectroscopy showed the polymerisation kinetic..View full abstract
Related Projects (1)
Awarded by Australian Research Council
The authors acknowledge the assistance of Flinders Analytical-Flinders University in obtaining the ESI-MS. The authors wish to acknowledge funding support from Commonwealth Scientific and Industrial Research Organization (CSIRO) and an Australian Research Council Future Fellowship grant (FT130100211).