Vagal afferent activation suppresses systemic inflammation via the splanchnic anti-inflammatory pathway
Evilin Naname Komegae, David George Stephen Farmer, Virginia Leah Brooks, Michael Joseph McKinley, Robin Michael McAllen, Davide Martelli
BRAIN BEHAVIOR AND IMMUNITY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2018
Electrical stimulation of the vagus nerve (VNS) is a novel strategy used to treat inflammatory conditions. Therapeutic VNS activates both efferent and afferent fibers; however, the effects attributable to vagal afferent stimulation are unclear. Here, we tested if selective activation of afferent fibers in the abdominal vagus suppresses systemic inflammation. In urethane-anesthetized rats challenged with lipopolysaccharide (LPS, 60 µg/kg, i.v.), abdominal afferent VNS (2 Hz for 20 min) reduced plasma tumor necrosis factor alpha (TNF) levels 90 min later by 88% compared with unmanipulated animals. Pre-cutting the cervical vagi blocked this anti-inflammatory action. Interestingly, the surgical ..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
Awarded by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
This work was supported by project grant number 1098887 from the National Health and Medical Research Council (NHMRC) of Australia and from the Victorian Government Operational Infrastructure Support Program. E. N. Komegae was the recipient of a postdoctoral fellowship from Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP 2016/1555-6).