Journal article
Longitudinal Preterm Cerebellar Volume: Perinatal and Neurodevelopmental Outcome Associations
LG Matthews, TE Inder, L Pascoe, K Kapur, KJ Lee, BB Monson, LW Doyle, DK Thompson, PJ Anderson
Cerebellum | SPRINGER | Published : 2018
Abstract
Impaired cerebellar development is an important determinant of adverse motor and cognitive outcomes in very preterm (VPT) infants. However, longitudinal MRI studies investigating cerebellar maturation from birth through childhood and associated neurodevelopmental outcomes are lacking. We aimed to compare cerebellar volume and growth from term-equivalent age (TEA) to 7 years between VPT (< 30 weeks’ gestation or < 1250 g) and full-term children; and to assess the association between these measures, perinatal factors, and 7-year outcomes in VPT children, and whether these relationships varied by sex. In a prospective cohort study of 224 VPT and 46 full-term infants, cerebellar volumes were mea..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by Australia's National Health and Medical Research Council (Centre for Clinical Research Excellence 546519 to LD, PA, and TI; Centre for Research Excellence 1060733 to LD, PA, and DT; Project grants 237117 to TI and LD, 491209 to PA, TI, LD, and DT; Senior Research Fellowship 1081288 to PA; Career Development Fellowship 1085754 to DT; Early Career Fellowship 1012236 to DT; Career Development Fellowship 1127984 to KJL), National Institutes of Health (HD058056), United Cerebral Palsy Foundation (USA), Leila Y. Mathers Charitable Foundation (USA), the Brown Foundation (USA), and the Victorian Government's Operational Infrastructure Support Program. This work was further conducted with support from Harvard Catalyst vertical bar The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, NIH Award UL1 TR001102) and financial contributions from Harvard University and its affiliated academic healthcare centers.