Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trial.

Leo H Bonati; John Gregson; Joanna Dobson; Dominick JH McCabe; Paul J Nederkoorn; H Bart van der Worp; Gert J de Borst; Toby Richards; Trevor Cleveland; Mandy D Müller; Thomas Wolff; Stefan T Engelter; Philippe A Lyrer; Martin M Brown; International Carotid Stenting Study investigators

Journal article

Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trial.

Leo H Bonati, John Gregson, Joanna Dobson, Dominick JH McCabe, Paul J Nederkoorn, H Bart van der Worp, Gert J de Borst, Toby Richards, Trevor Cleveland, Mandy D Müller, Thomas Wolff, Stefan T Engelter, Philippe A Lyrer, Martin M Brown, undefined International Carotid Stenting Study investigators

Lancet Neurol | Published : 2018

DOI: 10.1016/S1474-4422(18)30195-9

Abstract

BACKGROUND: The risk of stroke associated with carotid artery restenosis after stenting or endarterectomy is unclear. We aimed to compare the long-term risk of restenosis after these treatments and to investigate if restenosis causes stroke in a secondary analysis of the International Carotid Stenting Study (ICSS). METHODS: ICSS is a parallel-group randomised trial at 50 tertiary care centres in Europe, Australia, New Zealand, and Canada. Patients aged 40 years or older with symptomatic carotid stenosis measuring 50% or more were randomly assigned either stenting or endarterectomy in a 1:1 ratio. Randomisation was computer-generated and done centrally, with allocation by telephone or fax, st..

View full abstract