Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trial

LH Bonati; J Gregson; J Dobson; DJH McCabe; PJ Nederkoorn; HB van der Worp; GJ de Borst; T Richards; T Cleveland; MD Müller; T Wolff; ST Engelter; PA Lyrer; MM Brown; A Algra; SJ Bakke; N Baldwin; J Beard; C Bladin; JM Bland; J Boiten; M Bosiers; AW Bradbury; D Canovas; B Chambers; A Chamorro; J Chataway; A Clifton; R Collins; L Coward; A Czlonkowska; S Davis; L DeJaegher; D Doig; P Dorman; J Ederle; RF Featherstone; JM Ferro; P Gaines; G Gilling-Smith; M Goertler; A Gottsäter; W Hacke; A Halliday; G Hamilton; JMH Hendriks; M Hill; LJ Kapelle; M Kaste; F Kennedy; P Konrad; LJS Kool; PJ Koudstaal; I Malik; H Markus; P Martin; JL Mas; C McCollum; T McGahan; AJ McGuire; P Michel; A Molyneux; J Moroney; A Mosch; J Moss; R Naylor; A Peeters; D Roy; D Schultz; DM Seriki; RA Shinton; P Sidhu; J Stewart; G Subramanian; R Sztajzel; PG Than; D Thomas; E Turner; JSP van den Berg; G Vanhooren; G Venables; N Wahlgren; S Walker; C Warlow; B Zvan

Journal article

Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trial

LH Bonati, J Gregson, J Dobson, DJH McCabe, PJ Nederkoorn, HB van der Worp, GJ de Borst, T Richards, T Cleveland, MD Müller, T Wolff, ST Engelter, PA Lyrer, MM Brown, A Algra, SJ Bakke, N Baldwin, J Beard, C Bladin, JM Bland Show all

Lancet Neurology | ELSEVIER SCIENCE INC | Published : 2018

DOI: 10.1016/S1474-4422(18)30195-9

Abstract

Background: The risk of stroke associated with carotid artery restenosis after stenting or endarterectomy is unclear. We aimed to compare the long-term risk of restenosis after these treatments and to investigate if restenosis causes stroke in a secondary analysis of the International Carotid Stenting Study (ICSS). Methods: ICSS is a parallel-group randomised trial at 50 tertiary care centres in Europe, Australia, New Zealand, and Canada. Patients aged 40 years or older with symptomatic carotid stenosis measuring 50% or more were randomly assigned either stenting or endarterectomy in a 1:1 ratio. Randomisation was computer-generated and done centrally, with allocation by telephone or fax, st..

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