Journal article
High-resolution X-ray phase-contrast 3-d imaging of breast tissue specimens as a possible adjunct to histopathology
P Baran, S Mayo, M McCormack, S Pacile, G Tromba, C Dullin, F Zanconati, F Arfelli, D Dreossi, J Fox, Z Prodanovic, M Cholewa, H Quiney, M Dimmock, Y Nesterets, D Thompson, P Brennan, T Gureyev
IEEE Transactions on Medical Imaging | Published : 2018
Abstract
Histopathological analysis is the current gold standard in breast cancer diagnosis and management, however, as imaging technology improves, the amount of potential diagnostic information that may be demonstrable radiologically should also increase. We aimed to evaluate the potential clinical usefulness of 3-D phase-contrast micro-computed tomography (micro-CT) imaging at high spatial resolutions as an adjunct to conventional histological microscopy. Ten breast tissue specimens, 2 mm in diameter, were scanned at the SYRMEP beamline of the Elettra Synchrotron using the propagation-based phase-contrast micro-tomography method. We obtained 1.2μm pixel size images, which were analyzed and compare..
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Awarded by Australian Nuclear Science and Technology Organisation
Funding Acknowledgements
This work was supported in part by the National Breast Cancer Foundation, Australia (Breast cancer: transforming diagnosis, radiation dose and compression discomfort through phase-contrast 3D computed tomography) under Grant IN-16-001 and in part by the International Synchrotron Access Program managed by the Australian Synchrotron, part of ANSTO, Australian Government.