Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
Emma J Petrie, Jarrod J Sandowl, Annette Jacobsen, Brian J Smith, Michael DW Griffin, Isabelle S Lucet, Weiwen Dai, Samuel N Young, Maria C Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D Cowan, Joanne M Hildebrand, Wilhelmus JA Kersten, Guillaume Lessene, John Silke, Peter E Czabotar, Andrew Webb, James M Murphy
Nature Communications | NATURE PUBLISHING GROUP | Published : 2018
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Awarded by National Health and Medical Research Council
Awarded by Australian Research Council
We thank staff at the Australian Synchrotron SAXS/WAXS and MX beamlines for assistance with data collection, the Collaborative Crystallisation Centre (Parkville) for assistance with protein crystallization, Patrick Hennessy for technical assistance and Adeline Robin for MX data collection. We acknowledge Australian Government Research Training Program Stipend Scholarship support to A.V.J. and a Victorian International Research Scholarship to M.C.T. We are grateful to the National Health and Medical Research Council for fellowship (G.L., 1117089; J.S., 1058190; P.E.C., 1079700; J.M.M., 1105754), grant (1057905; 1124735), and infrastructure (IRIISS 9000433) support; the Australian Research Council (Future Fellowship to M.D.W.G., FT140100544); Australian Cancer Research Foundation; and the Victorian Government Operational Infrastructure Support scheme.