Journal article
Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography
CA McDevitt, CA Shintre, J Günter Grossmann, NL Pollock, SM Prince, R Callaghan, RC Ford
FEBS Letters | ELSEVIER SCIENCE BV | Published : 2008
Abstract
P-glycoprotein (ABCB1) is an ATP-binding cassette protein that is associated with the acquisition of multi-drug resistance in cancer and the failure of chemotherapy in humans. Structural insights into this protein are described using a combination of small angle X-ray scattering data and cryo-electron crystallography data. We have compared the structures with bacterial homologues, and discuss the development of homology models for P-glycoprotein based on the bacterial Sav1866 structure. © 2008 Federation of European Biochemical Societies.
Grants
Awarded by Medical Research Council
Funding Acknowledgements
We thank Drs. Ian Kerr (University of Nottingham), Megan O'Mara (University of British Columbia), Kenneth Linton (MRC Clinical Sciences Centre, Hammersmith) and Clair Baldock (University of Manchester) for useful discussions, encouragement and advice This work is funded by Project Grants from Cancer Research UK (C362/A5806) and the Medical Research Council UK (G040063).