Journal article
A large retrospective cohort study of cefazolin compared with flucloxacillin for methicillin-susceptible Staphylococcus aureus bacteraemia
JS Davis, J Turnidge, SYC Tong
International Journal of Antimicrobial Agents | ELSEVIER SCIENCE BV | Published : 2018
Abstract
Background and objectives: Antistaphylococcal penicillins (ASPs) are recommended as first-line treatment for invasive infections caused by methicillin-susceptible Staphylococcus aureus (MSSA). Cefazolin is an alternative option, but there is theoretical concern about its use as some MSSA strains produce beta-lactamases active against cefazolin. The study compared the outcomes in patients with MSSA infections treated with flucloxacillin and cefazolin. Methods: We analysed data from The Australia and New Zealand Co-operative Outcomes of Staphylococcal Sepsis (ANZCOSS) observational study, which included all consecutive unique episodes of Staphylococcus aureus bacteraemia from 27 hospital-based..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
Support for ANZCOSS data collection was generously granted by the Australian Society for Antimicrobials. The Australian Society for Antimicrobials had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. JSD and SYT received salary support from Australia's National Health and Medical Research Council (Career Development Fellowships #1083105 and #1065736, respectively).