Journal article

Magnetic Nanoparticles Coated with a Thermosensitive Polymer with Hyperthermia Properties

Felisa Reyes-Ortega, Angel V Delgado, Elena K Schneider, BL Checa Fernandez, GR Iglesias

POLYMERS | MDPI | Published : 2018

Abstract

Magnetic nanoparticles (MNPs) have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Their incorporation into biopolymer coatings enables the preparation of magnetic field-responsive, biocompatible nanoparticles that are well dispersed in aqueous media. Here we describe a synthetic route to prepare functionalized, stable magnetite nanoparticles (MNPs) coated with a temperature-responsive polymer, by means of the hydrothermal method combined with an oil/water (o/w) emulsion process. The effects of both pH and temperature on the electrophoretic mobility and surface charge of these MNP..

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Grants

Awarded by Junta de Andalucia


Awarded by MINECO


Awarded by MINECO Ramon y Cajal programme


Funding Acknowledgements

This research work is supported by Junta de Andalucia (PE2012-FQM694); MINECO (FIS2013-47666-C3-1R), Feder Funds UE; and MINECO Ramon y Cajal programme (RYC-2014-16901).