Magnetic Nanoparticles Coated with a Thermosensitive Polymer with Hyperthermia Properties
Felisa Reyes-Ortega, Angel V Delgado, Elena K Schneider, BL Checa Fernandez, GR Iglesias
POLYMERS | MDPI | Published : 2018
Magnetic nanoparticles (MNPs) have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Their incorporation into biopolymer coatings enables the preparation of magnetic field-responsive, biocompatible nanoparticles that are well dispersed in aqueous media. Here we describe a synthetic route to prepare functionalized, stable magnetite nanoparticles (MNPs) coated with a temperature-responsive polymer, by means of the hydrothermal method combined with an oil/water (o/w) emulsion process. The effects of both pH and temperature on the electrophoretic mobility and surface charge of these MNP..View full abstract
Awarded by Junta de Andalucia
Awarded by MINECO
Awarded by MINECO Ramon y Cajal programme
This research work is supported by Junta de Andalucia (PE2012-FQM694); MINECO (FIS2013-47666-C3-1R), Feder Funds UE; and MINECO Ramon y Cajal programme (RYC-2014-16901).