Journal article

Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3

Sameer A Greenall, Jacqueline Donoghue, Terrance G Johns, Timothy E Adams



Hepatocellular carcinoma (HCC) is highly refractory to current therapeutics used in the clinic. DX-2647, a recombinant human antibody, potently neutralizes the action of insulin-like growth factor-II (IGF-II), a ligand for three cell-surface receptors (IGF-IR, insulin receptor A and B isoforms, and the cation-independent mannose-6-phosphate receptor) which is overexpressed in primary human HCC. DX-2647 impaired the growth of tumor xenografts of the HCC cell line, Hep3B; however, xenografts of the HCC cell line, HepG2, were largely unresponsive to DX-2647 treatment. Analysis of a number of aspects of the IGF signaling axis in both cell lines did not reveal any significant differences between ..

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Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

T. G. J. (GNT1117501) is supported by a fellowship from the National Health and Medical Research Council of Australia. We acknowledge assistance through the Victorian Government's Operational and Infrastructure Support Program.