What is chronic fatigue syndrome? Heterogeneity within an international multicentre study.
A Wilson, I Hickie, D Hadzi-Pavlovic, D Wakefield, G Parker, SE Straus, J Dale, D McCluskey, G Hinds, A Brickman, D Goldenberg, M Demitrack, T Blakely, S Wessely, M Sharpe, A Lloyd
Aust N Z J Psychiatry | Published : 2001
OBJECTIVE: We sought to compare the characteristics of patients presenting with chronic fatigue (CF) and related syndromes in eight international centres and to subclassify these subjects based on symptom profiles. The validity of the subclasses was then tested against clinical data. METHOD: Subjects with a clinical diagnosis of CF completed a 119-item self-report questionnaire to provide clinical symptom data and other information such as illness course and functional impairment. Subclasses were generated using a principal components-like analysis followed by latent profile analysis (LPA). RESULTS: 744 subjects returned complete data sets (mean age 40.8 years, mean length of illness 7.9 yea..View full abstract