The Effect of Noninvasive High-Frequency Oscillatory Ventilation on Desaturations and Bradycardia in Very Preterm Infants: A Randomized Crossover Trial

CM Rüegger; L Lorenz; COF Kamlin; BJ Manley; LS Owen; D Bassler; DG Tingay; SM Donath; PG Davis

Journal article

The Effect of Noninvasive High-Frequency Oscillatory Ventilation on Desaturations and Bradycardia in Very Preterm Infants: A Randomized Crossover Trial

CM Rüegger, L Lorenz, COF Kamlin, BJ Manley, LS Owen, D Bassler, DG Tingay, SM Donath, PG Davis

Journal of Pediatrics | MOSBY-ELSEVIER | Published : 2018

DOI: 10.1016/j.jpeds.2018.05.029

Abstract

Noninvasive high-frequency oscillatory ventilation compared with nasal continuous positive airway pressure significantly reduced the number of desaturations and bradycardia in preterm infants. However, noninvasive high-frequency oscillatory ventilation was associated with increased oxygen requirements and higher heart rates. Trial registration: Australian and New Zealand Clinical Trial Registry: ACTRN12616001516471.

University of Melbourne Researchers

Omar Kamlin Author

Brett J. Manley Author

Louise S Owen Author

David Tingay Author

Related Projects (2)

IMPROVING THE HEALTH OF NEWBORN INFANTS

Birth is a complex process and sometimes babies require help to make the transition to independent life. Professor Peter Davis is conducting..

BREATHING EASIER: OPTIMISING NON-INVASIVE VENTILATION OF PRETERM INFANTS

Every year in Australia more than 6000 premature babies need breathing support after birth. My research focuses on improving the application..

Grants

Awarded by State Government of Victoria

Funding Acknowledgements

Supported by the Swiss National Science Foundation (Early Postdoctoral Mobility fellowship P2ZHP3_161749 [to C.R.]); the Swiss Society of Neonatology (Milupa Fellowship Award [to C.R.]); the German Research Society (DFG-grant Nr. LO 2162/1-1 [to L.L.]); the TUFF Habilitation Program (TUFF 2459-0-0 [to L.L.]); Victorian Government Operational Infrastructure Support Program (Melbourne, Australia); the National Health and Medical Research Council (Practitioner Fellowship GNT 1059111 [to P.D.]; Early Career Fellowships GNT 1073533 [to C.O.K.], GNT 1088279 [to B.M.], GNT 1090678 [to L.O.]; Career Development Fellowships GNT 11123859 and 1057514 [to D.T.]). The authors declare no conflicts of interest.