Journal article
Trehalose elevates brain zinc levels following controlled cortical impact in a mouse model of traumatic brain injury
SD Portbury, DJ Hare, DP Bishop, DI Finkelstein, PA Doble, PA Adlard
Metallomics | OXFORD UNIV PRESS | Published : 2018
DOI: 10.1039/c8mt00068a
Abstract
Zinc (Zn) deficiency is a clinical consequence of brain injury that can result in neuropathological outcomes that are exacerbated with age. Here, we present laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) imaging data showing modulation of brain Zn levels by the disaccharide trehalose in aged mice following a controlled cortical impact model of traumatic brain injury. In this proof-of-concept study, trehalose induced an increase in brain zinc levels, providing important preliminary data for larger studies using this simple carbohydrate as a modulator of this essential micronutrient in traumatic brain injury. Our results may have further implications for the treatment ..
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Awarded by Australian Research Council
Funding Acknowledgements
DJH is supported by an Australian National Health and Medical Research Council Career Development Fellowship (APP1120582) with Agilent Technologies. DJH and PAD are supported by an Australian Research Council Linkage Project (LP120200081) with Agilent Technologies and ESI Ltd. PAA was supported by an Australian Research Council Future Fellowship (FT120100030). In addition, the Florey Institute of Neuroscience and Mental Health acknowledge the strong support from the Victorian Government and the funding from the Operational Infrastructure Support Grant. The Elemental Bio-imaging Facility receives material support from Agilent Technologies. We would like to acknowledge the excellent technical assistance provided by Charlotte J. Sgambelloni during the surgical procedures undertaken for these experiments.