Journal article
The Vascularised Chamber as an In Vivo Bioreactor
KK Yap, GC Yeoh, WA Morrison, GM Mitchell
Trends in Biotechnology | ELSEVIER SCIENCE LONDON | Published : 2018
Abstract
Vascularisation is key to developing large transplantable tissue constructs capable of providing therapeutic benefits. The vascularised tissue engineering chamber originates from surgical concepts in tissue prefabrication and microsurgery. It serves as an in vivo bioreactor in the form of a closed, protected space surgically created and embedded within the body by fitting a noncollapsible chamber around major blood vessels. This creates a highly angiogenic environment which facilitates the engraftment and survival of transplanted cells and tissue constructs. This article outlines the chamber concept and explores its application in the context of recent advances in biomedical engineering, and..
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Funding Acknowledgements
The authors gratefully acknowledge funding from the Australian National Health & Medical Research Council (NHMRC), Stafford Fox Foundation, St Vincent's Hospital Melbourne Research Endowment Fund, Australian Catholic University, Bioplatforms Australia, University of Melbourne Centre for Stem Cell Systems, and the Victorian State Government's Department of Business Innovation Operational Infrastructure Support Program. K.K.Y. has received an Australian Government Research Training Program Scholarship, and research scholarships from the NHMRC, Australian and New Zealand Hepatic, Pancreatic and Biliary Association, and St Vincent's Institute Foundation, Melbourne.