Journal article
Renin-angiotensin-aldosterone system genotype and serum BNP in a contemporary cohort of adults late after Fontan palliation
LJ Burchill, AN Redington, CK Silversides, HJ Ross, L Jimenez-Juan, S Mital, EN Oechslin, A Dragulescu, C Slorach, L Mertens, RM Wald
International Journal of Cardiology | ELSEVIER IRELAND LTD | Published : 2015
Abstract
Abstract Background Adults with single ventricle physiology palliated with a Fontan circulation experience high mortality due to circulatory failure. Renin-angiotensin-aldosterone system (RAAS) genotype contributes to adverse cardiovascular outcomes in acquired heart failure. This study evaluated associations between RAAS genotype, ventricular mass and function in a contemporary cohort of adults with a Fontan circulation. Methods This single-center prospective study included adults (n = 106) seen after the Fontan operation (mean age 27 ± 9 years). Patients were genotyped for 5 pro-hypertrophic RAAS gene polymorphisms. Serum BNP, ventricular mass and function, and clinical events were compare..
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Funding Acknowledgements
The authors would like to acknowledge the support of Mr. David Walker and his contribution towards the cardiac imaging component of this study and the assistance of Dr Tara Paton and Ms Carol-Ann Ryan from The Centre for Applied Genomics, Hospital for Sick Children, Toronto, for their assistance with DNA extraction and RAAS genotyping of patients. Funding for this study was provided by the Dean's Fund at the University of Toronto.