Impact of adult congenital heart disease on survival and mortality after heart transplantation

Abstract

BACKGROUND: Reduced early survival has been reported in adult congenital heart disease (ACHD) heart transplant (HTx) recipients, but little is known about late outcomes after HTx. The aim of this study was to examine survival; causes of death; and predictors of early (5 years) mortality in ACHD HTx recipients. METHODS: ACHD patients undergoing HTx between 1985 and 2010 were identified in the transplant registry of the International Society for Heart and Lung Transplantation (ISHLT). Survival was compared between ACHD and other adult HTx recipients ("controls") using the Kaplan-Meier method. Factors associated with survival beyond 1 year were assessed using multivariable proportional hazards ..