Journal article

Pantoprazole or Placebo for Stress Ulcer Prophylaxis (POP-UP): Randomized Double-Blind Exploratory Study

Shane P Selvanderan, Matthew J Summers, Mark E Finnis, Mark P Plummer, Yasmine Ali Abdelhamid, Michael B Anderson, Marianne J Chapman, Christopher K Rayner, Adam M Deane

Critical Care Medicine | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016

Abstract

OBJECTIVES: Pantoprazole is frequently administered to critically ill patients for prophylaxis against gastrointestinal bleeding. However, comparison to placebo has been inadequately evaluated, and pantoprazole has the potential to cause harm. Our objective was to evaluate benefit or harm associated with pantoprazole administration. DESIGN: Prospective randomized double-blind parallel-group study. SETTING: University-affiliated mixed medical-surgical ICU. PATIENTS: Mechanically ventilated critically ill patients suitable for enteral nutrition. INTERVENTIONS: We randomly assigned patients to receive either daily IV placebo or pantoprazole. MEASUREMENTS AND MAIN RESULTS: Major outcomes were cl..

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Grants

Funding Acknowledgements

Supported, in part, by a project grant from the Royal Adelaide Hospital Research Foundation.Dr. Selvanderan received funding from the Royal Adelaide Hospital Research Foundation (honours scholarship). His institution received funding from the Royal Adelaide Hospital Research Foundation (project grant). Mr. Summers' institution received funding from the Royal Adelaide Hospital Research Foundation (project grant). Dr. Ali Abdelhamid received funding (the project was funded by a project grant from the Royal Adelaide Hospital Research Foundation). Dr. Rayner disclosed off-label product use (pantoprazole for prevention of stress ulceration). His institution received funding from the Royal Adelaide Hospital Research Foundation (project grant), AstraZeneca, Merck, and Novartis. Dr. Deane was supported by an early career fellowship from the National Health and Medical Research Council. His institution received funding from the Royal Adelaide Hospital Research Foundation (project grant). The remaining authors have disclosed that they do not have any potential conflicts of interest.