Prior exposure to hyperglycaemia attenuates the relationship between glycaemic variability during critical illness and mortality
Mark P Plummer, Mark E Finnis, Matthew Horsfall, Marleesa Ly, Palash Kar, Yasmine Ali Abdelhamid, Adam M Deane
Critical Care and Resuscitation | AUSTRALASIAN MED PUBL CO LTD | Published : 2016
OBJECTIVE: Our primary objective was to determine the impact of prior exposure to hyperglycaemia on the association between glycaemic variability during critical illness and mortality. Our secondary objectives included evaluating the relationships between prior hyperglycaemia and hyperglycaemia or hypoglycaemia during critical illness and mortality. DESIGN AND PARTICIPANTS: A single-centre, retrospective, observational study in a tertiary intensive care unit. Patients admitted to the ICU between 1 September 2011 and 30 June 2015, with diabetes recorded using ICD-10-AM coding or a glycated haemoglobin (HbA1c) level of ≥ 6.5%, were stratified by prior hyperglycaemic level (HbA1c 8.5%). MAIN O..View full abstract
Mark Plummer was supported by a National Health and Medical Research Council (NHMRC) Postgraduate Scholarship. Yasmine Ali Abdelhamid and Palash Kar are supported by Royal Adelaide Hospital Clarkson Scholarships. Adam Deane is partially supported by an NHMRC Early Career Fellowship.