Journal article

The effect of camicinal (GSK962040), a motilin agonist, on gastric emptying and glucose absorption in feed-intolerant critically ill patients: a randomized, blinded, placebo-controlled, clinical trial

Marianne J Chapman, Adam M Deane, Stephanie L O'Connor, Nam Q Nguyen, Robert JL Fraser, Duncan B Richards, Kimberley E Hacquoil, Lakshmi S Vasist Johnson, Matthew E Barton, George E Dukes

Critical Care | BIOMED CENTRAL LTD | Published : 2016


BACKGROUND: The promotility agents currently available to treat gastroparesis and feed intolerance in the critically ill are limited by adverse effects. The aim of this study was to assess the pharmacodynamic effects and pharmacokinetics of single doses of the novel gastric promotility agent motilin agonist camicinal (GSK962040) in critically ill feed-intolerant patients. METHODS: A prospective, randomized, double-blind, parallel-group, placebo-controlled, study was performed in mechanically ventilated feed-intolerant patients [median age 55 (19-84), 73 % male, APACHE II score 18 (5-37) with a gastric residual volume ≥200 mL]. Gastric emptying and glucose absorption were measured both pre- a..

View full abstract


Funding Acknowledgements

The study was supported by an unrestricted grant from GlaxoSmithKline to Intensive Care Research at the Royal Adelaide Hospital. MJC, AMD, SLO'C, NQN and RJLF did not receive payment, stock, or travel grants from GlaxoSmithKline and have no duality of interest. DBR, KEH, LSVJ, GED are employees at, and all hold stock in, GlaxoSmithKline. MEB is a previous employee of GlaxoSmithKline. There are no other competing interests.