The insulinotropic effect of pulsatile compared with continuous intravenous delivery of GLP-1
Mark P Plummer, Palash Kar, Caroline E Cousins, Kylie Lange, Marianne J Chapman, Michael A Nauck, Michael Horowitz, Juris J Meier, Adam M Deane
Diabetologia | SPRINGER | Published : 2016
AIMS/HYPOTHESIS: In healthy individuals, both insulin and glucagon-like peptide 1 (GLP-1) are secreted in a pulsatile fashion. Insulin has greater glucose-lowering properties when administered in pulses compared with a constant i.v. infusion. The primary aim of this randomised double-dummy cross-over study was to compare the insulinotropic response to pulsatile and continuous i.v. infusions of equivalent doses of GLP-1. METHODS: Twelve healthy participants aged 18-35 years were randomised to three different treatments on separate days: a continuous infusion day (GLP-1 at 0.6 pmol kg(-1) min(-1) [1 ml/min] and a 1 ml placebo bolus every 6 min); a pulsatile infusion day (placebo at 1 ml/min an..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
This study was supported by Project Grant 1025648 from the National Health and Medical Research Council (NHMRC) of Australia. MPP is supported by an NHMRC postgraduate scholarship and AMD is supported by an NHMRC Early Career Fellowship.