Hyperglycemia Potentiates the Slowing of Gastric Emptying Induced by Exogenous GLP-1
Mark P Plummer, Karen L Jones, Caroline E Cousins, Laurence G Trahair, Juris J Meier, Marianne J Chapman, Michael Horowitz, Adam M Deane
Diabetes Care | AMER DIABETES ASSOC | Published : 2015
OBJECTIVE: Acute hyperglycemia markedly slows gastric emptying. Exogenous GLP-1 also slows gastric emptying, leading to diminished glycemic excursions. The primary objective was to determine whether hyperglycemia potentiates the slowing of gastric emptying induced by GLP-1 administration. RESEARCH DESIGN AND METHODS: Ten healthy participants were studied on 4 separate days. Blood glucose was clamped at hyperglycemia using an intravenous infusion of 25% dextrose (∼12 mmol/L; hyper) on 2 days, or maintained at euglycemia (∼6 mmol/L; eu) on 2 days, between t = -15 and 240 min. During hyperglycemic and euglycemic days, participants received intravenous GLP-1 (1.2 pmol/kg/min) and placebo in a ra..View full abstract
Awarded by National Health and Medical Research Council of Australia
Awarded by National Health and Medical Research Council
The study was supported by Project Grant 1025648 from the National Health and Medical Research Council of Australia. K.L.J.'s salary is provided by a National Health and Medical Research Council Senior Career Development Award (627011).