Journal article

The gut-brain axis in the critically ill: Is glucagon like peptide-1 protective in neurocritical care?

Mark P Plummer, Juris J Meier, Adam M Deane

CRITICAL CARE | BMC | Published : 2013


Enteral nutrient is a potent glucagon-like peptide-1 (GLP-1) secretagogue. In vitro and animal studies indicate that GLP-1 has immune-modulatory and neuroprotective effects. To determine whether these immune-modulatory and neuroprotective effects of GLP-1 are beneficial in the critically ill, studies achieving pharmacological GLP-1 concentrations are warranted.

University of Melbourne Researchers

Funding Acknowledgements

Prof Daren Heyland was awarded the 2012 Royal Adelaide Hospital Nimmo Professorship. The Nimmo Professorship facilitated collaboration required for this study.