Journal article
The gut-brain axis in the critically ill: Is glucagon-like peptide-1 protective in neurocritical care?
MP Plummer, JJ Meier, AM Deane
Critical Care | BMC | Published : 2013
DOI: 10.1186/cc12758
Abstract
Enteral nutrient is a potent glucagon-like peptide-1 (GLP-1) secretagogue. In vitro and animal studies indicate that GLP-1 has immune-modulatory and neuroprotective effects. To determine whether these immune-modulatory and neuroprotective effects of GLP-1 are beneficial in the critically ill, studies achieving pharmacological GLP-1 concentrations are warranted. © 2013 BioMed Central Ltd.
Funding Acknowledgements
Prof Daren Heyland was awarded the 2012 Royal Adelaide Hospital Nimmo Professorship. The Nimmo Professorship facilitated collaboration required for this study.