Endogenous glucagon-like peptide-1 slows gastric emptying in healthy subjects, attenuating postprandial glycemia

Abstract

Introduction: The role of glucagon-like peptide-1 (GLP-1) in the regulation of gastric emptying is uncertain. The aim of this study was to determine the effects of endogenous GLP-1 on gastric emptying, glucose absorption, and glycemia in health. Methods: Ten healthy fasted subjects (eight males, two females; 48±7 yr) received the specific GLP-1 antagonist, exendin(9-39) amide [ex(9-39)NH2] (300 pmol/kg • min iv), or placebo, between -30 and 180 min in a randomized, double-blind, crossover fashion. At 0 min, a mashed potato meal (∼2600 kJ) containing 3 g 3-ortho-methyl-D-glucose (3-OMG) and labeled with 20 MBq 99mTechnetium-sulphur colloid was eaten. Gastric emptying, including the time taken..