Journal article

The Metallophore Staphylopine Enables Staphylococcus aureus To Compete with the Host for Zinc and Overcome Nutritional Immunity

Kyle P Grim, Brian San Francisco, Jana N Radin, Erin B Brazel, Jessica L Kelliher, Paola K Parraga Solorzano, Philip C Kim, Christopher A McDevitt, Thomas E Kehl-Fie

MBIO | AMER SOC MICROBIOLOGY | Published : 2017

Abstract

During infection, the host sequesters essential nutrients, such as zinc, to combat invading microbes. Despite the ability of the immune effector protein calprotectin to bind zinc with subpicomolar affinity, Staphylococcus aureus is able to successfully compete with the host for zinc. However, the zinc importers expressed by S. aureus remain unknown. Our investigations have revealed that S. aureus possesses two importers, AdcABC and CntABCDF, which are induced in response to zinc limitation. While AdcABC is similar to known zinc importers in other bacteria, CntABCDF has not previously been associated with zinc acquisition. Concurrent loss of the two systems severely impairs the ability of S. ..

View full abstract

Grants

Awarded by National Institutes of Health


Awarded by National Health and Medical Research Council


Awarded by Australian Research Council


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This work was supported by grants from the National Institutes of Health (K22 AI104805 and R01 AI118880) and a March of Dimes Basil O'Connor award to T.E.K.-F. and by National Health and Medical Research Council (project grants 1080784 and 1122582) and Australian Research Council (Discovery Projects DP150104515 and DP170102102) grants to C.A.M. B.S.F. was funded by an Institute for Genomic Biology Postdoctoral Fellowship.