Journal article
Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium
TGM van Erp, E Walton, DP Hibar, L Schmaal, W Jiang, DC Glahn, GD Pearlson, N Yao, M Fukunaga, R Hashimoto, N Okada, H Yamamori, JR Bustillo, VP Clark, I Agartz, BA Mueller, W Cahn, SMC de Zwarte, HE Hulshoff Pol, RS Kahn Show all
Biological Psychiatry | ELSEVIER SCIENCE INC | Published : 2018
Abstract
Background: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group. Methods: The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11–78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10–87 years; 53% male) assessed with standardized methods at 39 centers worldwide. Results: Compared with healthy volun..
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Awarded by Scoliosis Research Society
Funding Acknowledgements
The ENIGMA project is in part supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (Grant No. U54EB020403). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Acknowledgments for the various participating data contributors are listed in Supplement 1.