Journal article

Coxiella burnetii (Q-Fever) Seroprevalence in Prey and Predators in the United Kingdom: Evaluation of Infection in Wild Rodents, Foxes and Domestic Cats Using a Modified ELISA

AL Meredith, SC Cleaveland, MJ Denwood, JK Brown, DJ Shaw

Transboundary and Emerging Diseases | WILEY | Published : 2015


Coxiella burnetii, the agent of Q-fever, is recognized as a worldwide zoonosis with a wide host range and potentially complex reservoir systems. Infected ruminants are the main source of infection for humans, but cats and other mammals, including wild rodents, also represent potential sources of infection. There has been a recent upsurge of reported cases in humans, domestic ruminants and wildlife in many parts of the world, and studies have indicated that wild brown rats may act as true reservoirs for C. burnetii and be implicated in outbreaks in livestock and humans. However, investigation of reservoir systems is limited by lack of validated serological tests for wildlife or other non-targ..

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University of Melbourne Researchers


Awarded by Defra

Funding Acknowledgements

The authors would like to thank Anna LeCoq of IDVet for her valued assistance and for provision of the ELISA kits, and Dr. Alan Pemberton for his assistance and advice. This project was funded by Defra project grant no SE01526. Thanks to Forestry Commission, United Utilities and the Balfour Estate for access to trapping sites, to all those who contributed fox carcases, and to the participating veterinary surgeons who collected cat samples.