Journal article

Neutralizing Antibody-Based Prevention of Cell-Associated HIV-1 Infection

Matthew S Parsons, Roger Le Grand, Stephen J Kent

VIRUSES-BASEL | MDPI | Published : 2018

Abstract

Improved vaccine-mediated protection against HIV-1 requires a thorough understanding of the mode of HIV-1 transmission and how various immune responses control transmission. Cell-associated HIV-1 is infectious and contributes to HIV-1 transmission in humans. Non-human primate models of cell-associated SIV infection demonstrate that cell-associated SIV is more infectious than cell-free SIV. In a recently described chimeric simian⁻human immunodeficiency virus (SHIV) macaque model, it was demonstrated that an occult infection with cell-associated SHIV can be established that evades passive protection with a broadly neutralizing antibody (bnAb). Indeed, considerable in vitro data shows that bnAb..

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University of Melbourne Researchers

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by European Union's Horizon research and innovation program


Awarded by Australian NHMRC-EU collaborative grant


Funding Acknowledgements

This work was funded by grants 1101813 and 1124680 from the Australian National Health and Medical Research Council (NHMRC). Partial support was provided by the European Union's Horizon 2020 research and innovation program under grant agreement no. 681032 (European AIDS Vaccine Initiative) and an Australian NHMRC-EU collaborative grant (1115828).