Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study

MA Tubi; E Lutkenhoff; MB Blanco; D McArthur; P Villablanca; B Ellingson; R Diaz-Arrastia; P Van Ness; C Real; V Shrestha; J Engel; PM Vespa; D Agoston; A Au; MJ Bell; T Bleck; C Branch; M Buitrago Blanco; R Bullock; BT Burrows; J Claassen; R Clarke; J Cloyd; L Coles; K Crawford; D Duncan; B Foreman; A Galanopoulou; E Gilmore; G Olli; N Harris; J Hartings; H Lawrence; M Hunn; N Jette; L Johnston; N Jones; A Kanner; M Monti; A Morokoff; S Moshe; W Mowrey; T O'Brien; K O'Phelan; A Pitkanen; R Raman; C Robertson; E Rosenthal; S Shultz; T Snutch; R Staba; A Toga; J Van Horn; P Vespa; F Willyerd; L Zimmermann

Journal article

Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study

MA Tubi, E Lutkenhoff, MB Blanco, D McArthur, P Villablanca, B Ellingson, R Diaz-Arrastia, P Van Ness, C Real, V Shrestha, J Engel, PM Vespa, D Agoston, A Au, MJ Bell, T Bleck, C Branch, M Buitrago Blanco, R Bullock, BT Burrows Show all

Neurobiology of Disease | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019

DOI: 10.1016/j.nbd.2018.05.014

Abstract

Objective: Injury severity after traumatic brain injury (TBI) is a well-established risk factor for the development of post-traumatic epilepsy (PTE). However, whether lesion location influences the susceptibility of seizures and development of PTE longitudinally has yet to be defined. We hypothesized that lesion location, specifically in the temporal lobe, would be associated with an increased incidence of both early seizures and PTE. As secondary analysis measures, we assessed the degree of brain atrophy and functional recovery, and performed a between-group analysis, comparing patients who developed PTE with those who did not develop PTE. Methods: We assessed early seizure incidence (n = 9..

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University of Melbourne Researchers

Prof Leigh Johnston Author

A/Prof Andrew Morokoff Author

Grants

Awarded by National Institute of Neurological Disorders and Stroke

Funding Acknowledgements

This manuscript was supported by the following grants: NS080181, NS058489, PT074268, NS049471, K08 NS02089, NS086090. NINDS Center without Walls, U54 NS100064 (EpiBioS4Rx).