The small molecule drug diminazene aceturate inhibits liver injury and biliary fibrosis in mice
Indu G Rajapaksha, Kai Y Mak, Ping Huang, Louise M Burrell, Peter W Angus, Chandana B Herath
SCIENTIFIC REPORTS | NATURE PORTFOLIO | Published : 2018
There is no established medical therapy to treat biliary fibrosis resulting from chronic inflammation in the biliary tree. We have recently shown that liver-specific over-expression of angiotensin converting enzyme 2 (ACE2) of the renin angiotensin system (RAS) ameliorated liver fibrosis in mice. Diminazene aceturate (DIZE), a small molecule drug approved by the US Food and Drug Administration, which is used to treat human trypanosomiasis, has been shown to have antifibrotic properties by enhancing ACE2 activity. In this study we sought to determine the therapeutic potential of DIZE in biliary fibrosis using bile duct ligated and multiple drug resistant gene-2 knockout mice. Additionally, hu..View full abstract
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Awarded by Australian National Health and Medical Research Council (NHMRC)
We gratefully acknowledge Zhiyuan Jia for her expert technical assistance. This work was supported by Australian National Health and Medical Research Council (NHMRC) project grants (APP1062372 and APP1124125).